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Registro Completo |
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Biblioteca(s): |
Epagri-Sede. |
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Data corrente: |
26/11/2018 |
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Data da última atualização: |
26/11/2018 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
HEIDRICH, D.; CORBELLINI, V. A.; MENDES, S. D. C.; FERNANDES, E. K.; LAZZAROTTO, L.; RIBEIRO, A. C.; ZANETTE, R. A.; SCROFERNEKER, M. L. |
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Título: |
Melanin: Quantification and protection against oxidative stress in chromoblastomycosis agents. |
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Ano de publicação: |
2018 |
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Fonte/Imprenta: |
Medical Mycology, Oxford, v. 56, n. 3, p. 1-7, 2018. |
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Idioma: |
Inglês |
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Conteúdo: |
Chromoblastomycosis (CBM) is a chronic cutaneous and subcutaneous
infection caused by melanized fungal species. We quantified the extractable
melanin of 77 strains of CBM agents distributed within five genera.
Moreover, resistance to oxidative stress was evaluated in strains exposed
or not to the melanin inhibitor tricyclazole. The median percentage of
melanin mass extracted from dry fungal mass varied from 0.69
(Rhinocladiella similis) to 3.81 (Phialophora americana). Inhibition of
melanin synthesis decreased survival rates to hydrogen peroxide.
Together, these data highlight the importance of melanin in CBM agents. |
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Palavras-Chave: |
DHN-MELANIN; Fonsecaea; Phialophora; Tricyclozole. |
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Categoria do assunto: |
F Plantas e Produtos de Origem Vegetal |
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Marc: |
LEADER 01356naa a2200253 a 4500
001 1128029
005 2018-11-26
008 2018 bl uuuu u00u1 u #d
100 1 $aHEIDRICH, D.
245 $aMelanin$bQuantification and protection against oxidative stress in chromoblastomycosis agents.$h[electronic resource]
260 $c2018
520 $aChromoblastomycosis (CBM) is a chronic cutaneous and subcutaneous infection caused by melanized fungal species. We quantified the extractable melanin of 77 strains of CBM agents distributed within five genera. Moreover, resistance to oxidative stress was evaluated in strains exposed or not to the melanin inhibitor tricyclazole. The median percentage of melanin mass extracted from dry fungal mass varied from 0.69 (Rhinocladiella similis) to 3.81 (Phialophora americana). Inhibition of melanin synthesis decreased survival rates to hydrogen peroxide. Together, these data highlight the importance of melanin in CBM agents.
653 $aDHN-MELANIN
653 $aFonsecaea
653 $aPhialophora
653 $aTricyclozole
700 1 $aCORBELLINI, V. A.
700 1 $aMENDES, S. D. C.
700 1 $aFERNANDES, E. K.
700 1 $aLAZZAROTTO, L.
700 1 $aRIBEIRO, A. C.
700 1 $aZANETTE, R. A.
700 1 $aSCROFERNEKER, M. L.
773 $tMedical Mycology, Oxford$gv. 56, n. 3, p. 1-7, 2018.
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