01356naa a2200253 a 450000100080000000500110000800800410001910000170006024501220007726000090019952006290020865300160083765300140085365300160086765300170088370000220090070000210092270000210094370000190096470000190098370000190100270000240102177300570104511280292018-11-26       2018    bl uuuu     u00u1 u    #d1 aHEIDRICH, D.  aMelaninbQuantification and protection against oxidative stress in chromoblastomycosis agents.h[electronic resource]  c2018  aChromoblastomycosis (CBM) is a chronic cutaneous and subcutaneous infection caused by melanized fungal species. We quantified the extractable melanin of 77 strains of CBM agents distributed within five genera. Moreover, resistance to oxidative stress was evaluated in strains exposed or not to the melanin inhibitor tricyclazole. The median percentage of melanin mass extracted from dry fungal mass varied from 0.69 (Rhinocladiella similis) to 3.81 (Phialophora americana). Inhibition of melanin synthesis decreased survival rates to hydrogen peroxide. Together, these data highlight the importance of melanin in CBM agents.  aDHN-MELANIN  aFonsecaea  aPhialophora  aTricyclozole1 aCORBELLINI, V. A.1 aMENDES, S. D. C.1 aFERNANDES, E. K.1 aLAZZAROTTO, L.1 aRIBEIRO, A. C.1 aZANETTE, R. A.1 aSCROFERNEKER, M. L.  tMedical Mycology, Oxfordgv. 56, n. 3, p. 1-7, 2018.