02628naa a2200253 a 450000100080000000500110000800800410001910000190006024501890007926000090026852017960027765300160207365300200208965300260210965300180213565300210215370000190217470000190219370000210221270000260223370000180225970000210227777300760229811245252015-10-26       2015    bl uuuu     u00u1 u    #d1 aANSANTE, T. F.  aSecondary metabolites from Neotropical AnnonaceaebScreening,bioguided fractionation, and toxicity to Spodoptera frugiperda (J.E.Smith) (Lepidoptera: Noctuidae).h[electronic resource]  c2015  aAnnonaceae species are interesting sources of structurally diverse compounds with insecticidal proper-ties. Therefore, a screening assay was conducted on ethanolic extracts prepared from the leaves, branches,and seeds of different Annonaceae species (Annona cacans Warming, Annona montana Macfadyen, Annonamucosa Jacquin, Annona reticulata Linnaeus, Annona sylvatica A. St.-Hil., and Duguetia lanceolata A. St.-Hil.) to detect promising sources of compounds with action against Spodoptera frugiperda (J.E. Smith)(Lepidoptera: Noctuidae). The ethanolic extract from A. mucosa seeds (ESAM) was the most active treat-ment, causing significant acute toxicity (LC50= 842.9 mg kg−1) and pronounced larval growth inhibition(EC50= 580.4 mg kg−1) after 7 days of exposure to an ESAM-treated diet. Furthermore, ethanolic extracts(at 1000 mg kg−1) from seeds of A. cacans, A. montana, A. mucosa, and A. sylvatica; leaves and branches of A.reticulata; and D. lanceolata leaves only caused sublethal effects, reducing the S. frugiperda larval weight.Nevertheless, ESAM (at LC90) showed an efficacy similar to that of two commercial insecticides of nat-ural [azadirachtin + 3-tigloylazadirachtol (Azamax??1.2 EC)] and synthetic [chlorantraniliprole (Premio??20 SC)] origins, which were tested at the registered concentration for S. frugiperda control. Thus, usingdifferent chromatographic techniques, bioguided fractionations were conducted and led to the isolationof acetogenin bis-tetrahydrofuran rolliniastatin-1, which was identified as the primary compound fromthe most active fractions of ESAM. This compound, which caused both strong mortality and pronouncedgrowth inhibition to S. frugiperda, may be a useful component for the integrated management of thisimportant pest species.  aAcetogenins  aAllelochemicals  aBotanical insecticide  aFall armyworm  aRolliniastatin-11 aRIBEIRO, L. P.1 aBICALHO, K. U.1 aFERNANDES, J. B.1 aSILVA, M. F. G. A. F.1 aVIEIRA, P. C.1 aVENDRAMIM, J. D.  tIndustrial Crops and Products, The Netherlandgv. 74, p. 969-976, 2015.