Data/hora: 16/06/2024 08:10:10

Biblioteca(s): | Epagri-Sede.
Data corrente: | 12/12/2022
Data da última atualização: | 12/12/2022
Autoria: | NOLDIN JÚNIOR, L.; AMORIM,, P. C.; MENDES, S. D. C.; ARCARI,, S. G.; PILATI, S. F. M.
Título: | Prevention Of Oral Epithelial Dysplasia And Neoplasya Using Guabiroba Extract: A Study With Wistar Rats.
Ano de publicação: | 2022
Fonte/Imprenta: | Australian Journal of Basic and Applied Sciences , Puducherry, v. 16, n. 10, p. 6-12, 2022.
Idioma: | Inglês

Conteúdo:

In recent years, studies focused on the total antioxidant activity present in native fruits in Brazil
due to the compounds present with properties of reducing the level of oxidative stress and consequently reducing
the risk of several cardiovascular, neurodegenerative and cancer. Objective: The aim of the study was to analyze
the effects of guabiroba fruit extract on chemically induced carcinogenesis in rats. METHODS: Carcinogenesis was
chemically induced by the compound 9,10-dimethyl-1,2-benzanthracene in oral mucosa applications in Wistar
rats using only the carcinogen in the control group, the gel vehicle, application of pure extract and for the
experimental group, applications of 9,10-dimethyl-1,2-benzanthracene and topical application of guabiroba pulp
extract in 24 rats divided into 4 groups. After 60 days, the animals were euthanized to collect tissue samples. The
tissue samples were analyzed in a microscope using Hematoxylin Eosin coloration with World Health
Organization criteria. RESULTS: Cases of moderate and intense dysplasia were found in 66.7% of the animals in
the control group and 33.3% in the experimental group. In pure extract group and gel vehicle group animals, there
were no cases of moderate and intense epithelial dysplasia. Inflammatory infiltrate was found in 100 % of the
slides of the control group; in 33.3 % of the experimental group only and in 16. 7% of the pure extract group and
the gel vehicle group. The results showed that there was a difference between the control and experimental
groups, i.e., in the control group, which was only in contact with the 9,10-dimethyl-1,2-benzanthracene, dysplasia
occurred in whole animals. In comparison, in the experimental group, in addition to the carcinogen, the guabiroba
extract was also applied, and there were half as many samples with dysplasia. Conclusion:9,10-dimethyl-1,2-
benzanthracene proved to be effective in promoting chemical carcinogenesis and should be used in rat animal
models of oral cancer. The results found in this study showed that guabiroba fruit extract has the ability to reduce
the formation of epithelial dysplasia, suggesting its preventive efficacy; in addition, it can reduce the presence of
inflammatory infiltrate in oral mucosa.

Thesagro: | Antioxidants; Carcinogenesis; Inflammation; Squamous cell carcinoma.
Categoria do assunto: | L Ciência Animal e Produtos de Origem Animal
URL: | http://intranetdoc.epagri.sc.gov.br/producao_tecnico_cientifica/DOC_55800.pdf
Registro original: | Epagri-Sede (Epagri-Sede)
Exemplares: | Epagri-Sede - (107836-1) - UPC - AP - DD -  -  -  - DIS