Data/hora: 07/06/2024 12:04:32

Biblioteca(s): | Epagri-Sede.
Tipo da produção científica: | Artigo em Periódico Indexado
Circulação/Nível: | Internacional - A
Data corrente: | 10/11/2021
Data da última atualização: | 10/11/2021
Autoria: | LIMA, A. F.; RIBEIRO, L. P.; GONÇALVES, G. L. P.; MAIMONE, N. M.; GISSI, D. S.; LIRA, S. P.; VENDRAMIM, J. D.
Título: | Searching for bioactive compounds from Solanaceae: lethal and sublethal toxicity to Spodoptera frugiperda and untargeted metabolomics approaches.
Ano de publicação: | 2021
Fonte/Imprenta: | Journal of Pest Science, Dordrecht, p. 1-13, 2021.
Idioma: | Inglês

Conteúdo:

The fall armyworm, Spodoptera frugiperda (J.E. Smith) (Lepidoptera: Noctuidae), is a major pest of maize crops and others
row crops on the American continent, and this pest has spread to Africa and Asia. Such lepidopteran pest presents resistant
populations to synthetic insecticides and to Bacillus thuringiensis (Bt) toxins and, consequently, new (bio) insecticides with
distinct modes of action are required. In order to search for derivatives from Solanaceae as a potential source of bioactive
compounds, a screening of 38 ethanolic extracts were prepared from 25 Solanaceae species. Using dietary exposure assessment,
the ethanolic extracts from leaves of Acnistus arborescens (L.) Schltdl. and Datura stramonium L. were the most
promising derivatives. A bioguided fractionation was performed with both plant species. The A. arborescens dichloromethane
fraction was the most active, causing sublethal (growth inhibition) and lethal toxicity. Thus, this fraction was submitted
to another fractionation procedure resulting in three subfractions (dichloromethane, ethyl acetate and methanol) that were
tested against S. frugiperda caterpillars. All subfractions lead to significant sublethal effects, however, without significant
mortality. The chemical diversity in the subfractions of A. arborescens was assessed through untargeted approaches, such
as molecular networking and the in silico annotation tool NAP, by which two withanolides glycosides were annotated:
(22R)-1-Oxo-3beta-(beta-D-glucopyranosyloxy)-14,20,22,27-tetrahydroxyergosta-5,24-diene-26-oic acid delta-lactone and
withanoside XI. Therefore, derivatives of Solanaceae present promising compounds that may be useful in the framework of
S. frugiperda integrated pest management. In addition, metabolomics is an innovative alternative and powerful approach to
facilitate the putative identification of compounds in studies of natural products.

Palavras-Chave: | Acnistus arborescens; Botanical insecticides; Chromatographic procedures; Datura stramonium; Fall armyworm; Withanolides.
Categoria do assunto: | O Insetos e Entomologia
URL: | http://intranetdoc.epagri.sc.gov.br/producao_tecnico_cientifica/DOC_50289.pdf
Registro original: | Epagri-Sede (Epagri-Sede)
Exemplares: | Epagri-Sede - (106421-1) - UPC - AP - DD -  -  -  - DIS