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Registro Completo |
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Biblioteca(s): |
Epagri-Sede. |
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Data corrente: |
15/04/2021 |
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Data da última atualização: |
15/04/2021 |
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Tipo da produção científica: |
Resumo em Anais de Congresso |
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Autoria: |
CRISTO, T. G.; PINTO, M. G. L.; VALENTE, T. C.; HACK, A. K. C.; PEREIRA, D. G.; FERNANDES, N. C. C. A.; BORGES, C. S. C.; CASAGRANDE, R. A. |
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Título: |
MEDULLOBLASTOMA IN A CALF OF THE FLEMISH BREED. |
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Ano de publicação: |
2019 |
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Fonte/Imprenta: |
In: CONGRESSO BRASILEIRO DE PATOLOGIA VETERINÁRIA, 5., ENCONTRO NACIONAL DE PATOLOGIA VETERINÁRIA, 19., 2019, Ribeirão Preto. Resumos... Botucatu, SP: Associação Brasileira de Patologia Veterinária, 2019. p. 154 |
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Idioma: |
Inglês |
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Conteúdo: |
Medulloblastomas are neuroectodermal tumors of embryonic origin developing in cerebellum and spinal cord
and have an unusual occurrence. When it occurs in cattle, it is observed in neonatal cases, leading to multiple neurological
clinical signs. Flemish cattle are considered at risk of extinction and the rare specimens of Brazil are in Lages, Santa
Catarina. Case Report: The case of a two-month-old calf with difficulty remaining in a standing position, imbalance,
opisthotonus, strabismus, and broad-based gait is described in this study. Results: The animal was euthanized, and the
necropsy showed an irregular, whitish pink, and friable mass in the cerebellar vermis region, measuring 5×6×3.8 cm
associated with the dilation of the lateral ventricles, which extended through the interventricular foramen, midbrain
aqueduct, and fourth ventricle. Histologically, it presented elongated triangular neuronal cells arranged in a dense sheet that
sometimes encircled small areas of neuropil to form Homer-Wright pseudorosettes. These characteristic tumors were
compatible with a medulloblastoma. The tumor immunohistochemical (IHC) evaluation demonstrated a positive staining for
vimentin in neoplastic cells and glial fibrillary acidic protein in neoplastic stromal cells, non-reactive for synaptophysin, and
negative for S100 protein and pan-cytokeratin. Tests for differential diagnosis as PCR for Neospora caninum and RT-PCR
for BVDV were carried out and both results were negative. Conclusions: The histological and topographical characteristics
were paramount for determining the medulloblastoma diagnosis and the IHC panel is similar to that observed in other
studies. Tumor growth is limited by skull bony structures, allowing to determine that the clinical signs expressed by the
animal were directly related to the compression of important functional structures due to tumor expansion. Medulloblastoma
is an unusual tumor in all the animal species, not previously reported in Flemish cattle, and necropsy followed by
histopathological examination is essential for the diagnosis. MenosMedulloblastomas are neuroectodermal tumors of embryonic origin developing in cerebellum and spinal cord
and have an unusual occurrence. When it occurs in cattle, it is observed in neonatal cases, leading to multiple neurological
clinical signs. Flemish cattle are considered at risk of extinction and the rare specimens of Brazil are in Lages, Santa
Catarina. Case Report: The case of a two-month-old calf with difficulty remaining in a standing position, imbalance,
opisthotonus, strabismus, and broad-based gait is described in this study. Results: The animal was euthanized, and the
necropsy showed an irregular, whitish pink, and friable mass in the cerebellar vermis region, measuring 5×6×3.8 cm
associated with the dilation of the lateral ventricles, which extended through the interventricular foramen, midbrain
aqueduct, and fourth ventricle. Histologically, it presented elongated triangular neuronal cells arranged in a dense sheet that
sometimes encircled small areas of neuropil to form Homer-Wright pseudorosettes. These characteristic tumors were
compatible with a medulloblastoma. The tumor immunohistochemical (IHC) evaluation demonstrated a positive staining for
vimentin in neoplastic cells and glial fibrillary acidic protein in neoplastic stromal cells, non-reactive for synaptophysin, and
negative for S100 protein and pan-cytokeratin. Tests for differential diagnosis as PCR for Neospora caninum and RT-PCR
for BVDV were carried out and both results were negative. Conclusions... Mostrar Tudo |
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Palavras-Chave: |
central nervous system; neoplasm; neuropathology; ruminant. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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Marc: |
LEADER 02953naa a2200253 a 4500
001 1130738
005 2021-04-15
008 2019 bl uuuu u00u1 u #d
100 1 $aCRISTO, T. G.
245 $aMEDULLOBLASTOMA IN A CALF OF THE FLEMISH BREED.$h[electronic resource]
260 $c2019
520 $aMedulloblastomas are neuroectodermal tumors of embryonic origin developing in cerebellum and spinal cord and have an unusual occurrence. When it occurs in cattle, it is observed in neonatal cases, leading to multiple neurological clinical signs. Flemish cattle are considered at risk of extinction and the rare specimens of Brazil are in Lages, Santa Catarina. Case Report: The case of a two-month-old calf with difficulty remaining in a standing position, imbalance, opisthotonus, strabismus, and broad-based gait is described in this study. Results: The animal was euthanized, and the necropsy showed an irregular, whitish pink, and friable mass in the cerebellar vermis region, measuring 5×6×3.8 cm associated with the dilation of the lateral ventricles, which extended through the interventricular foramen, midbrain aqueduct, and fourth ventricle. Histologically, it presented elongated triangular neuronal cells arranged in a dense sheet that sometimes encircled small areas of neuropil to form Homer-Wright pseudorosettes. These characteristic tumors were compatible with a medulloblastoma. The tumor immunohistochemical (IHC) evaluation demonstrated a positive staining for vimentin in neoplastic cells and glial fibrillary acidic protein in neoplastic stromal cells, non-reactive for synaptophysin, and negative for S100 protein and pan-cytokeratin. Tests for differential diagnosis as PCR for Neospora caninum and RT-PCR for BVDV were carried out and both results were negative. Conclusions: The histological and topographical characteristics were paramount for determining the medulloblastoma diagnosis and the IHC panel is similar to that observed in other studies. Tumor growth is limited by skull bony structures, allowing to determine that the clinical signs expressed by the animal were directly related to the compression of important functional structures due to tumor expansion. Medulloblastoma is an unusual tumor in all the animal species, not previously reported in Flemish cattle, and necropsy followed by histopathological examination is essential for the diagnosis.
653 $acentral nervous system
653 $aneoplasm
653 $aneuropathology
653 $aruminant
700 1 $aPINTO, M. G. L.
700 1 $aVALENTE, T. C.
700 1 $aHACK, A. K. C.
700 1 $aPEREIRA, D. G.
700 1 $aFERNANDES, N. C. C. A.
700 1 $aBORGES, C. S. C.
700 1 $aCASAGRANDE, R. A.
773 $tIn: CONGRESSO BRASILEIRO DE PATOLOGIA VETERINÁRIA, 5., ENCONTRO NACIONAL DE PATOLOGIA VETERINÁRIA, 19., 2019, Ribeirão Preto. Resumos... Botucatu, SP: Associação Brasileira de Patologia Veterinária, 2019. p. 154
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